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In some studies, the Thr metabolism-related product -aminobutyric acid (AABA) has been shown to suppress the expression of pro-inflammatory macrophage-related genes and to jointly restrain inflammatory responses through metabolic reprogramming and EZH2-dependent epigenetic regulation, suggesting that the effects of amino acid metabolism on macrophage function may also extend to the level of metabolism-epigenetic coupling (67)

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Expression of peroxisome proliferator-activated receptor- in key neuronal subsets regulating glucose metabolism and energy homeostasis

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